Designing biocompatible protein nanoparticles for improving the cellular uptake and antioxidation activity of tetrahydrocurcumin

Tetrahydrocurcumin (THC) is a natural molecule with anticancerous, antioxidant and other beneficial activities. However, its low aqueous solubility leads to poor bioavailability. Sodium caseinate (NaCas) an ideal protein carrier amphiphilic non-toxic properties, which provides new possibility for improving the of THC. In this study, THC loaded nanoparticles ([email protected]) were successfully prepared by nanoprecipitation method. The protein-based awarded encapsulation efficiency about 98% structure physicochemical characteristics [email protected] characterized Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction, Scanning Electron Microscopy (SEM). test comfirmed that greater Furthermore, had activity compared free THC, resulting in radical scavenging ability 2.6 times than vitro cytotoxicity showed stronger inhibitory effect on cancer cells good biocompatibility non-cancerous cells. short, Our results demonstrate have potential improve bioactivity hydrophobic drugs clinical application.